The McVicker Laboratory is located at the Salk Institute for Biological Studies in beautiful La Jolla, California. We are part of the Laboratory of Genetics and the Integrative Biology Laboratory. We are also part of the Bioinformatics and Systems Biology program at UCSD.
The McVicker laboratory studies how human genetic variation affects gene regulation by combining experimental approaches with computational analyses. We are especially interested in identifying regulatory variants that affect human traits by altering gene expression in immune cells and cancer cells. Currently, we are developing new tools to discover regulatory mutations in cancer genomes, and manipulating cell lines with high-throughput CRISPR technologies to discover new regulatory sequences and interpret non-coding genetic variation. In much of our research, we develop computational and statistical methods to extract subtle signals from experimental data.