Join Us!

We are an interdisciplinary group of researchers studying the genetics of chromatin and gene regulation. We welcome inquiries from individuals from diverse experimental, computational and statistical backgrounds.

Our laboratory uses naturally occurring human genetic variation and genetic perturbations to understand how the genome specifies chromatin state and organization. We are also interested in linking regulatory variation with disease risk. In much of our research we develop statistical and computational methods so that we can analyze and interpret data from genomics experiments such as ChIP-seq, ATAC-seq and CRISPR screens. If this type of research sounds exciting to you, contact us.

About the Salk Institute

The Salk Institute is a great place to work! It was founded in 1960 by Jonas Salk, the developer of the polio vaccine, and was designed by the renowned architect Louis Kahn. Today, the Salk Institute is an architectural landmark and is one of the top biological research institutes in the world.

The Salk Institute is located in beautiful La Jolla, a community of San Diego, California. It is close to many other world-class research institutes including the University of California San Diego, the Scripps Research Insitute, the La Jolla Insitute for Allergy and Immunology, the Sanford Burnham Prebys Medical Discovery Institute and the J. Craig Venter Institute. Many biotechnology companies such as Illumina, Novartis and Human Longevity Inc. are also nearby.

Open Position: Postdoctoral Researcher - Quantitative trait mapping of single cell gene expression and chromatin traits

We are seeking a postdoctoral fellow interested in developing new statistical and computational methods to map single cell gene expression and chromatin traits. The successful candidate will have the opportunity analyze large single-cell ATAC-seq and single-cell RNA-seq datasets. These datasets are being collected by our collaborators at UCSD, and will be used to better understand the genetic basis of complex diseases including opioid addiction and type 1 diabetes.

Applicants should have a strong quantitative background and must have, or expect to receive, a Ph.D. in a relevant discipline (Genetics, Computer Science, Statistics, Bioinformatics, etc.).

Required skills / experience:
  • Experience with Python or other scripting language
  • Experience in R or other data analysis language
  • Experience in statistics and/or machine learning
  • Proficiency in Unix / Linux
  • Proficiency in scientific writing and communication
  • Contributions to published papers/preprints
  • Strong interest in biology, chromatin, and gene regulation
Desired skills:
  • Experience with bioinformatics tools / software
  • Experience working with next-generation sequencing data
  • Knowledge of human genetics
  • Experience in the anlaysis of single-cell data

Graduate Students

Graduate students can join the McVicker Lab through training programs at UCSD. We are a part of the Bioinformatics and Systems Biology program and are accepting rotation students. Interested students from other programs at UCSD are encouraged to contact the lab to discuss the possibility of rotating.


We welcome inquiries from postdoctoral candidates who wish to tackle cutting-edge research problems in human genetics, chromatin biology and immunology. Individuals should have strong quantitive and/or experimental backgrounds. Applicants must have, or expect to receive, a Ph.D. in a relevant discipline (Computer Science, Genetics, Statistics, Molecular Biology, Immunology, Bioinformatics, etc). To apply: Email Graham () with a brief cover letter describing your background and research interests, your CV, and contact information for 2-3 references.

Other Individuals

If you are interested in the lab, but don't see a relevant position listed here, please feel free to contact Graham () with an inquiry.


We are committed to diversity in science. We are therefore especially interested in receiving applications from women and underrepresented minorities.